Familial HBsAg-positive hepatoma: treatment with orthotopic liver transplantation and specific immunoglobulin.

during penicillamine treatment; fibrosing alveolitis during gold treatment; analgesic nephropathy in a patient who had taken chloroquine, cyclophosphamide, gold, indomethacin, naproxen, penicillamine, and phenylbutazone; and perforated duodenal ulcer with over 24 different drugs listed. Reported deaths listing gold increased gradually to a peak of eight in 1970; 18, including five of the seven "remote" ones, occurred in 1972-6 compared with 23 in the previous five years. The use of gold (ampoules a year) has steadily increased, nearly two-and-a-half times as much being issued in 1976 as in 1964. The magnitude of error caused by using ECIO prescriptions for gold (1968-70)2 as a guide to the amount of gold used was considerable. On this basis each EC10 prescription would have been for 15 ampoules or 15 weeks' treatment at the usual rate of one ampoule a week. As in 1969 many patients were receiving maintenance treatment, then usually one ampoule a month, the underestimate would be even greater.